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TUG-499

SKU: orb1741460

Description

TUG-499 is a potent and selective agonist for the free fatty acid receptor 1 (FFAR1/GPR40) with an EC50 of 7.39 nM. It exhibits high selectivity over related receptors like FFA2, FFA3, and PPARγ. This compound is a valuable research tool for investigating FFAR1-mediated insulin secretion in both in vitro and in vivo models of type 2 diabetes.

Research Area

Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1206629-08-4
MW320.17
Purity99.93%
FormulaC16H11Cl2NO2
SMILESC(#CC1=CC=C(CCC(O)=O)C=C1)C=2C=C(Cl)N=C(Cl)C2
TargetPPAR,GPCR
SolubilityDMSO:22.5 mg/mL (70.28 mM);10% DMSO+90% Corn Oil:2 mg/mL (6.25 mM)

Bioactivity

Target IC50
FFAR1/GPR40:7.39(pEC50)
In Vitro
TUG-499 exhibits remarkable chemical stability, does not inhibit specific CYP enzymes or P-glycoprotein, and displays outstanding Caco-2 permeability. Its potent effects are observed on recombinant human FFA1 receptors as well as the INS-1E rat insulinoma cell line.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

PPARγ, TUG 499, TUG499, TUG-499, FFA2, GPR40
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

TUG-499 (orb1741460)

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% DMSO +
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% Tween 80 +
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Available Sizes

Select a size below

2 mg
¥ 910.00
1 ml x 10 mM (in DMSO)
¥ 1,170.00
5 mg
¥ 1,170.00
10 mg
¥ 1,430.00
25 mg
¥ 2,080.00
50 mg
¥ 2,600.00
100 mg
¥ 3,250.00
DispatchUsually dispatched within 3-5 working days
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