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UC2288

SKU: orb1297939

Description

UC2288 is a Sorafenib-derived small molecule that selectively reduces p21 protein levels without significantly altering its stability. This compound is used in research to study cell cycle regulation and apoptosis, with applications in both in vitro and in vivo cancer models.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number1394011-91-6
MW481.82
Purity99.75% (May vary between batches)
FormulaC20H18ClF6N3O2
SMILESFC(F)(F)c1ccc(O[C@H]2CC[C@@H](CC2)NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)nc1
TargetMdm2,Apoptosis,MDM-2/p53,p53
Solubility10% DMSO+90% Corn Oil:2 mg/mL (4.15 mM);DMSO:48 mg/mL (99.62 mM)

Bioactivity

In Vivo
UC2288 (10 mg/kg; i.p.) attenuates MPTP-induced behavioral impairment, prevents activation of MAPK pathway in the MPTP-treated mice brain. MPTP treatment raises TNF-α, IL-6 and IL-1β levels in MPTP treated mice brain, but UC2288 signicantly decreases MPTP-induced TNF-α, IL-6 levels, but IL-1β is not decreased in brain.UC2888 (15 mg/kg; oral) co-treatment with imetelstat significantly suppresses tumor growth and does not effect mice weight.
In Vitro
UC2288 (0-10 μM; 24 hours) reduces p21 mRNA expression through transcriptional or post-transcriptional mechanisms, independent of p53, with no inhibition of VEGFR2 and Raf kinases, even at 10 μM.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

p53-mutant, inhibit, Inhibitor, HK2, MDM-2/p53, 786-O, Attenuator, cancer, sorafenib, RCC, p21, ovarian, UC-2288, UC2288, UC 2288
Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

UC2288 (orb1297939)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,170.00
1 ml x 10 mM (in DMSO)
¥ 1,820.00
5 mg
¥ 1,820.00
10 mg
¥ 2,470.00
25 mg
¥ 4,160.00
50 mg
¥ 5,980.00
100 mg
¥ 7,280.00
200 mg
¥ 8,840.00
500 mg
¥ 12,610.00
DispatchUsually dispatched within 3-5 working days
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