Upadacitinib

SKU: orb1299762

Description

Upadacitinib (ABT-494) is a potent and selective JAK1 inhibitor with an IC50 of 43 nM. It is widely used in research for autoimmune diseases, demonstrating efficacy in both in vitro assays and in vivo models of rheumatoid arthritis and inflammatory bowel disease.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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CAS Number	1310726-60-3
MW	380.37
Purity	99.94%
Formula	C₁₇H₁₉F₃N₆O
SMILES	CC[C@@H]1CN(C[C@@H]1c1cnc2cnc3[nH]ccc3n12)C(=O)NCC(F)(F)F
Target	JAK
Solubility	DMSO:55 mg/mL (144.6 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.63 mM)

Bioactivity

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Target IC50	JAK2:200 nM\|JAK1:43 nM\|JAK3:2.3 μM\|Tyk2:4.7 μM
In Vivo	Upadacitinib, a second JAK inhibitor, has been developed by AbbVie.Upadacitinib finished multiple-dose Phase I studies in 2013. Upadacitinib show to be safe and well-tolerated up to multiple doses of 24 mg twice daily using the immediate release formulation in phase I trials. Upadacitinib exposure is dose proportional to the evaluated multiple dose. Read more...
In Vitro	Upadacitinib is 74-fold more selective for JAK-1 than for JAK-2, which is involved in erythropoiesis. And Upadacitinib is 58-fold more selective for JAK-1 than for JAK-3, which is involved in immunosurveillance. The enhanced selectivity of Upadacitinib for JAK-1 over JAK-2 and JAK-3 may offer an improved benefit-risk profile in patients with RA range. Read more...

Storage & Handling

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Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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ABT494, ABT-494, ABT 494, autoimmune, Inhibitor, JAK2, JAK1, JAK, inhibit, Janus kinase, orally active, Upadacitinib

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Compound Identifiers

PubChem CID

58557659 ↗

Key Properties

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No computed properties available.

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Upadacitinib (orb1299762)

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Purity:	>98%
CAS Number:	2050057-56-0
MW:	398.382853269577
Formula:	C₁₇H₂₁F₃N₆O₂

CAS Number:	1607431-21-9
MW:	602.521
Formula:	C₂₁H₃₃F₃N₆O₁₁

MW:	383.37
Formula:	15NC₁₇H₁₇D₂F₃N₅O

Purity:	>98% (HPLC)
CAS Number:	1310726-60-3
MW:	380.4
Formula:	C₁₇H₁₉F₃N₆O

Upadacitinib

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Upadacitinib (orb1299762)

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