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Vilanterol

SKU: orb1701354

Description

Vilanterol

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Vilanterol

Key Properties

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CAS Number503068-34-6
MW486.43
Purity97.47% (May vary between batches)
FormulaC24H33Cl2NO5
SMILESOCc1cc(ccc1O)[C@@H](O)CNCCCCCCOCCOCc1c(Cl)cccc1Cl
TargetAdrenergic Receptor
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.11 mM);DMSO:50 mg/mL (102.79 mM)

Bioactivity

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Target IC50
β3-adrenoceptor:7.36±0.03(pEC50)|β1-adrenoceptor:6.98±0.03(pEC50)|β2-adrenoceptor:10.37±0.05(pEC50)
In Vitro
The selectivity of Vilanterol for β2-AR over other β-AR receptor subtypes (β2 and β3) is demonstrated through its ability to elicit concentration-dependent increases in cAMP in CHO cells expressing human β1-, β2-, and β3-AR. Vilanterol shows high selectivity for β2-AR with at least a 1000-fold preference over β2- and β3-AR subtypes. This analysis yields a low-affinity pKD for [3H]Vilanterol of 9.44±0.07 (n=4) in the presence of Gpp(NH)p and a high-affinity pKD of 10.82±0.12 (n=4) and a low-affinity pKD of 9.47±0.17 (n=4) in the absence of Gpp(NH)p. Additionally, a low-affinity pKD of 9.52±0.24 (n=4) is observed for [3H]Vilanterol in the absence of Gpp(NH)p at 37°C. Vilanterol trifenatate is a novel inhaled long-acting β2-agonist with 24-hour activity in vitro, developed in combination with the inhaled corticosteroid fluticasone furoate for the treatment of both COPD and asthma. Vilanterol is a novel long-acting β2-agonist (LABA) with 24-hour activity, intended for once-daily clinical treatment of COPD and asthma in combination with the 24-hour active corticosteroid fluticasone furoate.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Adrenergic Receptor, AdrenergicReceptor, Beta Receptor, inhibit, GW 642444, GW642444, GW-642444, GW642444X, Inhibitor, β1-adrenoceptor, β2-adrenoceptor, β3-adrenoceptor, Vilanterol

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID
10184665 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

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1 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 130.00
5 mg
$ 130.00
10 mg
$ 170.00
25 mg
$ 240.00
50 mg
$ 300.00
100 mg
$ 420.00
200 mg
$ 600.00
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