Vilanterol trifenatate

SKU: orb3027297

Description

Vilanterol trifenatate is a long-acting agonist of β2-adrenoceptor (β2-AR) with inherent 24-hour activity(β2-AR, β1-AR and β3-AR pEC50s of 10.37, 6.98 and 7.36, respectively)

Images & Validation

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Key Properties

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CAS Number	503070-58-4
MW	774.77
Purity	99.51%
Formula	C₄₄H₄₉Cl₂NO₇
SMILES	OCc1cc(ccc1OC(=O)C(c1ccccc1)(c1ccccc1)c1ccccc1)[C@@H](O)CNCCCCCCOCCOCc1c(Cl)cccc1Cl
Target	Adrenergic Receptor
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.58 mM);DMSO:100 mg/mL (129.07 mM)

Bioactivity

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Target IC50

β3-adrenoceptor:7.36±0.03(pEC50)|β2-adrenoceptor:10.37±0.05(pEC50) |β1-adrenoceptor:6.98±0.03(pEC50)

In Vivo

The preclinical pharmacological profile of vilanterol using radioligand binding and cAMP studies in recombinant assays as well as human and guinea pig tissue systems to characterize β(2)-AR binding and functional properties. Vilanterol displayed a subnanomolar affinity for the β(2)-AR that was comparable with that of salmeterol but higher than olodaterol, formoterol, and indacaterol. In cAMP functional activity studies, vilanterol demonstrated similar selectivity as salmeterol for β(2)- over β(1)-AR and β(3)-AR, but a significantly improved selectivity profile than formoterol and indacaterol. Vilanterol also showed a level of intrinsic efficacy that was comparable to indacaterol but significantly greater than that of salmeterol.

Storage & Handling

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Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Vilanterol, Vilanterol trifenatate, β1-adrenoceptor, β2-adrenoceptor, β3-adrenoceptor, Beta Receptor, AdrenergicReceptor, Adrenergic Receptor, GW 642444, GW642444, GW-642444, GW642444 (trifenatate), inhibit, Inhibitor

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Gene Symbol

Adrenergic Receptor

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