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W146

SKU: orb1708238

Description

W146 is a potent and selective S1PR1 antagonist used in research. It induces transient hematolymphopenia and pulmonary edema in murine models, making it a valuable tool for studying S1P signaling in immunology, inflammation, and vascular permeability.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number909725-61-7
MW342.37
Purity99.37% (May vary between batches)
FormulaC16H27N2O4P
SMILESN(C([C@@H](CCP(=O)(O)O)N)=O)C1=CC(CCCCCC)=CC=C1
TargetLPL Receptor,Apoptosis
SolubilityDMSO:15 mg/mL (43.81 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.84 mM)

Bioactivity

Target IC50
S1P1 receptor:70-80 nM(Ki)
In Vivo
In mice, Injections of W146, W140, JTE013, or Cay10444 do not alter the basal WBC count. when mice are pretreated with W146, it is found that a significant increase in KSL-HSPC mobilization, compared to that in mice pretreated with dextran followed by AMD3100 administration. Moreover, pre-treatment of W146 shows an approximately 8-fold increase of KSL-HSPC mobilization, measured by the CFU-G/M colony-forming assays, compared to that in mice treated with AMD3100 alone.
In Vitro
W146 is an antagonist of S1PR1 (Ki: 70-80 nM). W146 pretreatment significantly increased the TUNEL labeling index of endothelial progenitor cells (EPCs) compared with the S1P-treated group. W146 pretreatment significantly increased the level of activated cleaved caspase-3. S1P was able to reduce apoptosis in EPCs, but this protective effect was completely lost after W146 treatment.

Storage & Handling

Storagekeep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Apoptosis, LPL Receptor, LPLReceptor, S1PR1, W 146, W146, W-146

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Key Properties

No computed properties available.

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Protocol Information

W146 (orb1708238)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 ml x 10 mM (in DMSO)
1 mg
¥ 2,080.00
5 mg
¥ 6,500.00
10 mg
¥ 10,790.00
25 mg
¥ 20,930.00
50 mg
¥ 33,280.00