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YM-90709

SKU: orb1304505

Description

YM-90709

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number163769-88-8
MW359.42
Purity99.67%
FormulaC22H21N3O2
SMILESCOc1cc2CC(C)(C)n3c(cc4nc5ccccc5nc34)-c2cc1OC
TargetInterleukin,IL Receptor
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.56 mM);DMSO:18 mg/mL (50.08 mM)

Bioactivity

In Vivo
YM-90709 suppresses antigen-induced airway inflammation in Brown Norway rats. YM-90709 is a novel IL-5R antagonist with those of anit-IL-5 mAb o the antigen-induced infiltration of eosinophils int the airways of BDF1 mice, a strain that is commonly used in the antibody estimation. This in the first report o the examination o the effects of YM-90709 in vivo as a novel IL-5R antagonist o the antigen-induced infiltration of eosinophils and Other leukocytes int the BALF of Brown-Norway (BN) rats.
In Vitro
YM-90709 potently inhibit the binding of 100 pM [125I]-IL-5 to IL-5R on human peripheral eosinophils and eosinophilic HL-60 clone 15 cells with IC50 Values of 1. ± .40 and 0.5 ± .21 μM, respectively YM-90709 inhibit the 4 pM IL-5-induced effect in a concentration dependent manner with an IC50 value of 0.4 ± .024 μM. YM-90709 also inhibit the higher concentration (12 and 40 pM) of IL-5-induced effects with IC50 Values of 0.8 ± 29 and 1. ± .22 μM, respectively YM-90709 is a novel interleukin-5 receptor antagonist, YM-90709 inhibits antigen-induced eosinophil recruitment int the airway the same as anti-IL-5 mAb does. YM-90709 inhibit the binding of IL-5 to IL-5R on human eosinophils, but did not inhibi the binding of GM-CSF to GM-CSFR. In addition, YM-90709 inhibits IL-5-induced, but not GM-CSF-induced, eosinophil survival as well a the tyrosine phosphorylation of Janus kinase 2.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

JAK2, inhibit, ILReceptor, IL-5, IL-5R, Inhibitor, Interleukin Related, Interleukin, IL Receptor, eosinophils, GM-CSF, YM90709, YM-90709, YM 90709

Similar Products

  • YM-90709 [orb1226010]

    >98% (HPLC)

    163769-88-8

    359.4

    C22H21N3O2

    1 g, 500 mg, 200 mg, 10 mg, 25 mg, 100 mg, 2 mg, 5 mg, 50 mg
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Key Properties

No computed properties available.

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YM-90709 (orb1304505)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 910.00
2 mg
¥ 1,040.00
1 ml x 10 mM (in DMSO)
¥ 1,430.00
5 mg
¥ 1,430.00
10 mg
¥ 1,560.00
25 mg
¥ 2,730.00
50 mg
¥ 4,420.00
100 mg
¥ 6,370.00
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