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Z21115

SKU: orb2663581

Description

Z21115 is an orally effective phosphodiesterase 4 (PDE4) inhibitor that can inhibit PDE4D7 with an IC50 of 10.5 nM. It suppresses the expression of IL-6, TNF-α, and iNOS induced by Lipopolysaccharide. In a DSS-induced mouse colitis model, Z21115 demonstrates anti-inflammatory activity without significant toxicity at doses up to 1 g/kg.

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Key Properties

CAS Number2958668-54-5
MW390.38
FormulaC20H20F2N2O4
SMILESFC(F)OC1=CC=C(C=2C=C(OC)C(OC)=C(OC)C2)C3=CN(N=C13)C4CC4

Storage & Handling

Storage-20°C
DisclaimerFor research use only
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Z21115 (orb2663581)

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