2'-Hydroxychalcone

SKU: orb1684928

Description

2'-Hydroxychalcone is a synthetic flavonoid intermediate with demonstrated bioactivity in research models. In vitro, it induces cytotoxicity via oxidative stress in HepG2 cells and inhibits pro-inflammatory adhesion molecule expression. In vivo, a nanoemulsion formulation has shown antifungal efficacy against Candida parapsilosis in a zebrafish (Danio rerio) model.

Research Area

Cell Biology, Infectious Disease & Virology, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	1214-47-7
MW	224.25
Purity	98.09%
Formula	C₁₅H₁₂O₂
SMILES	Oc1ccccc1C(=O)\C=C\c1ccccc1
Target	Others,Antifungal,NF-κB,Apoptosis,Autophagy
Solubility	DMSO:27.5 mg/mL (122.63 mM)

Bioactivity

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Target IC50	mTOR:12 µM

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Disclaimer	For research use only

Alternative Names

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E-selectin, Fungal, ICAM-1, 1 (2 Hydroxyphenyl) 3 phenyl 2 propenone, 1(2Hydroxyphenyl)3phenyl2propenone, 2'-Hydroxychalcone, TNF-α, VCAM1

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Compound Identifiers

PubChem CID

638276 ↗

Key Properties

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No computed properties available.

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