Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

CLOZAPINE N-OXIDE

SKU: orb1222345

Description

Clozapine N-oxide is a major metabolite of clozapine that can be detected in the earliest excretion time interval after clozapine administration. It is produced by the action of cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4, whose activities, in turn, can be affected by drugs and disease. Clozapine N-oxide is normally biologically inactive. However, it can be used in designer receptor exclusively activated by designer drugs, also known as DREADDs, technology to modulate synthetic receptors in vivo.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number34233-69-7
MW342.82
Purity>98% (HPLC)
FormulaC18H19ClN4O
SMILESClc1ccc2Nc4ccccc4C(=Nc2c1)N3CC[N+]([O-])(C)CC3
TargetOthers
SolubilityDMSO : ≥ 100 mg/mL 291.70 mM; Methanol : ≥ 28.6 mg/mL 83.43 mM H2O : 1 mg/mL 2.92 mM

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Clozapine N-oxide

Similar Products

  • Clozapine N-Oxide [orb1302814]

    99.94% (May vary between batches)

    34233-69-7

    342.82

    C18H19ClN4O

    5 mg, 10 mg, 50 mg, 2 mg, 25 mg, 100 mg
  • Clozapine N-oxide dihydrochloride [orb1745121]

    98.11% (May vary between batches)

    2250025-93-3

    415.74

    C18H21Cl3N4O

    5 mg, 10 mg, 25 mg, 1 ml x 10 mM (in DMSO), 2 mg, 50 mg, 100 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

CLOZAPINE N-OXIDE (orb1222345)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

200 mg
500 mg
2 mg
¥ 910.00
5 mg
¥ 1,170.00
10 mg
¥ 1,690.00
25 mg
¥ 2,470.00
50 mg
¥ 3,510.00
100 mg
¥ 5,070.00