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Hydroxyfasudil

SKU: orb1302996

Description

Hydroxyfasudil is a potent and selective inhibitor of ROCK1 and ROCK2 kinases, exhibiting IC50 values of 0.73 and 0.72 μM, respectively. It is widely used in cardiovascular and neurological research to investigate Rho/ROCK pathway mechanisms in both cellular and animal models of hypertension, vasospasm, and stroke.

Research Area

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number105628-72-6
MW307.37
Purity98.79%
FormulaC14H17N3O3S
SMILESO=c1[nH]ccc2c(cccc12)S(=O)(=O)N1CCCNCC1
TargetROCK,PKA
Solubility10% DMSO+40% PEG300+5% Tween-80+45% Saline:0.5 mg/mL (1.63 mM);DMSO:31 mg/mL (100.86 mM)

Bioactivity

Target IC50
ROCK2:0.72 μM|ROCK1:0.73 μM|PKA:37 μM

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

inhibit, HA1100, HA-1100, HA 1100, Hydroxyfasudil, Hydroxy-Fasudil, Inhibitor, PKA, ROK, ROCK, ROCK1, ROCK2, Rho-kinase, Rho-associated kinase, Rho-associated protein kinase

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Key Properties

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Hydroxyfasudil (orb1302996)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 ml x 10 mM (in DMSO)
¥ 1,040.00
5 mg
¥ 1,040.00
10 mg
¥ 1,300.00
25 mg
¥ 1,820.00
50 mg
¥ 2,600.00
100 mg
¥ 3,770.00
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