Imiquimod

SKU: orb1310904

Description

Imiquimod (R 837) is a synthetic TLR7 agonist that functions as an immune response modifier with demonstrated antiviral and antitumor properties. It is widely used in research models of psoriasis and in studies investigating conditions such as viral warts, certain cancers, and COVID-19, utilizing both in vitro and in vivo experimental systems.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology

Images & Validation

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Key Properties

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CAS Number	99011-02-6
MW	240.30
Purity	99.66%
Formula	C₁₄H₁₆N₄
SMILES	C(C(C)C)N1C=2C=3C(N=C(N)C2N=C1)=CC=CC3
Target	SARS-CoV,HSV,TLR,Autophagy
Solubility	H2O:Insoluble;DMSO:1 mg/mL (4.16 mM)

Bioactivity

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In Vivo

In animal models, imiquimod stimulates the innate immune response by increasing NK cell activity, activating macrophages to secrete cytokines and nitric oxide, and inducing proliferation and differentiation of B lymphocytes. Imiquimod stimulates the innate immune response through induction, synthesis, and release of cytokines, including interferon-a (IFN-α), interleukin (IL)-6, and tumour necrosis factor (TNF)-α.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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squamous, SARS coronavirus, SARSCoV, SARS-CoV, S 26308, S26308, S-26308, TLR, TLR7, TLR8, Toll-like Receptor (TLR), warts, R 837, R837, R-837, vulvar, inhibit, infection, intraepithelial, IMQ, keratosis, nongenital, papillomavirus, neoplasia, molluscum, Inhibitor, Herpes simplex virus, Imiquimod, human, HSV, Autophagy, carcinoma, basal ,cell, Bowen's, actinic, cell, contagiosum, disease

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Compound Identifiers

PubChem CID

57469 ↗

Key Properties

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No computed properties available.

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Imiquimod (orb1310904)

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Purity:	>98%
CAS Number:	99011-78-6
MW:	276.7646
Formula:	C₁₄H₁₇CLN₄

Purity:	99.92%
CAS Number:	3026677-37-9
MW:	271.31
Formula:	C₁₉H₁₃NO

Purity:	99.98%
CAS Number:	99011-78-6
MW:	276.77
Formula:	C₁₄H₁₇ClN₄

CAS Number:	1189495-81-5
MW:	447.365
Formula:	C₁₅H₁₂BrFN₂O₂S₃

Imiquimod

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Imiquimod (orb1310904)

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