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Itacitinib

SKU: orb1226524

Description

A potent and selective JAK1 inhibitor; shows >20 fold and >200 fold selectivity over JAK2 and JAK3 respectively; orally bioactive.Blood Cancer Phase 2 Clinical(In Vitro):Itacitinib (INCB039110) is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2. Itacitinib is used in the research of myelofibrosis.

Images & Validation

Key Properties

CAS Number1334298-90-6
MW553.5142
Purity>98% (HPLC)
FormulaC26H23F4N9O
SMILESN#CCC1(N2N=CC(C3=C4C(NC=C4)=NC=N3)=C2)CN(C5CCN(C(C6=C(F)C(C(F)(F)F)=NC=C6)=O)CC5)C1
TargetJAK
SolubilityDMSO: ≥ 30 mg/mL

Bioactivity

In Vitro
Itacitinib (INCB039110) is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2. Itacitinib is used in the research of myelofibrosis.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

INCB-039110

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Protocol Information

Available Sizes

Select a size below

2 mg
$ 120.00
5 mg
$ 190.00
10 mg
$ 310.00
25 mg
$ 540.00
50 mg
$ 890.00
100 mg
$ 1,270.00
500 mg
$ 2,500.00