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Itacitinib

SKU: orb1303457

Description

Itacitinib

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number1334298-90-6
MW553.51
Purity97.57%
FormulaC26H23F4N9O
SMILESFc1c(ccnc1C(F)(F)F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
TargetJAK
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.61 mM);DMSO:150 mg/mL (271 mM)

Bioactivity

In Vivo
Itacitinib (INCB039110) produced significant improvements in sPGA, demonstrating proof of concept in chronic plaque psoriasis.
In Vitro
Itacitinib is an inhibitor of the Janus kinases (JAKs) with selectivity for JAK1.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Inhibitor, Janus kinase, JAK1, JAK, Itacitinib, inhibit, INCB 039110, INCB039110, INCB-039110, INCB 39110, INCB39110, INCB-39110

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Key Properties

No computed properties available.

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Itacitinib (orb1303457)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
¥ 1,430.00
5 mg
¥ 2,080.00
1 ml x 10 mM (in DMSO)
¥ 2,340.00
10 mg
¥ 2,990.00
25 mg
¥ 5,070.00
50 mg
¥ 8,060.00
100 mg
¥ 11,310.00
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