Medetomidine hydrochloride

SKU: orb1300641

Description

Medetomidine hydrochloride is a potent and highly selective α2-adrenoceptor agonist (Ki = 1.08 nM), demonstrating 1620-fold selectivity versus α1-adrenoceptors. It is widely used in research as a sedative and analgesic agent in both in vivo animal models and in vitro receptor binding studies.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	86347-15-1
MW	236.74
Purity	96.72%
Formula	C₁₃H₁₆N₂·HCl
SMILES	Cl.CC(c1c[nH]cn1)c1cccc(C)c1C
Target	Adrenergic Receptor
Solubility	DMSO:60 mg/mL (253.44 mM);H2O:23.7 mg/mL (100.11 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.45 mM)

Bioactivity

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Target IC50	α2-adrenoceptor:1.08 nM(Ki)\|α1-adrenoceptor:1750 nM (Ki)
In Vivo	In anesthetized rats, medetomidine (1-100 μg/kg, i.v.) induces a dose-dependent, relatively short-lived reduction in blood pressure and heart rate. In the pithed rat, medetomidine shows very potent vasopressor (PD50 1.7 μg/kg) and sympatho-inhibitory (ID50 1.6 μg/kg) effects without affecting basal heart rate. Medetomidine induces dose-dependent sedation, which at high doses (>100μg/kg) includes loss of the righting reflex and hypothermia. Medetomidine induces a decreases in the turnover rate of biogenic amines in the brain, dose-dependently inhibits norepinephrine (NE) turnover, inhibits brain dopamine turnover at high doses, decreases serotonin turnover. Read more...
In Vitro	Medetomidine is a selectiveα2-adrenoceptor agonist, with Ki of 1.08 nM, exhibits 1620-fold selectivity over α1-adrenoceptor, has very weak or no binding to other neurotransmitter receptors. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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anxiolysis, analgesia, Adrenergic Receptor, AdrenergicReceptor, central nervous system, Beta Receptor, Domitor, Medetomidine, Medetomidine HCl, Medetomidine hydrochloride, Medetomidine Hydrochloride, Inhibitor, inhibit, muscle relaxation, MPV 785, MPV785, MPV-785, sedation, peripheral nervous system, α2-adrenoceptor

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Compound Identifiers

PubChem CID

68601 ↗

Key Properties

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No computed properties available.

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