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Mianserin

SKU: orb1705061

Description

Mianserin is a tetracyclic antidepressant and H1 receptor reverse agonist used in research for its psychoactive properties. It is applied in studies of depression, anxiety, and sleep, utilizing in vitro binding assays and in vivo behavioral models to investigate its effects on norepinephrine and specific serotonin systems.

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number24219-97-4
MW264.36
Purity99.85%
FormulaC18H20N2
SMILESCN1CC2N(C=3C(CC=4C2=CC=CC4)=CC=CC3)CC1
TargetHistamine Receptor
SolubilityDMSO:Soluble;H2O:Insoluble

Bioactivity

In Vivo
The atypical antidepressant mianserin, administered at doses of 1, 5 and 10 mg/kg SC, dose-dependently increased up to about 6 times extracellular dopamine in the medial prefrontal cortex of the rat. Mianserin failed to modify extracellular dopamine in the nucleus accumbens. Mianserin also dose-dependently increased extracellular noradrenaline in the prefrontal cortex.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Tolvon, Lantanon, Lerivon, Histamine Receptor, HistamineReceptor, Norval, Lumin, Mianserin, Mianserine, Depnon

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Key Properties

No computed properties available.

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Mianserin (orb1705061)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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Available Sizes

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5 mg
¥ 1,040.00
10 mg
¥ 1,170.00
25 mg
¥ 1,690.00
DispatchUsually dispatched within 3-5 working days
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