PARP14 inhibitor 2

SKU: orb3027456

Description

PARP14 inhibitor2 (Compound 3) is an orally active and highly selective PARP14 inhibitor with an IC50 value of less than 30 nM. It effectively inhibits the mono ADP-ribosyltransferase activity of PARP14 and modulates IFN-γ and IL-4 signaling, thereby reversing pro-tumor macrophage polarization and suppressing anti-tumor inflammatory responses. PARP14 inhibitor2 holds potential for research in PARP14-related conditions such as tumors, atopic dermatitis, and autoimmune diseases.

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Key Properties

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CAS Number	3064731-00-3
MW	489.60
Formula	C₂₅H₃₂FN₃O₄S
SMILES	O=C1N=C(NC2=CC(OCC34CCC(NC(=O)C)(CC3)CC4)=CC(F)=C12)CSC5CCOCC5
Target	PARP

Storage & Handling

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Storage	-20°C
Disclaimer	For research use only

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PARP

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