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Semapimod

SKU: orb1944285

Description

Semapimod is an inhibitor of proinflammatory cytokine production, capable of suppressing TNF-α, IL-1β, and IL-6. It hinders TLR4 signaling with an IC50 of approximately 0.3 μM, impedes p38 MAPK, and reduces nitric oxide production in macrophages. This compound shows promise for treating various inflammatory and autoimmune disorders.

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction

Images & Validation

Key Properties

CAS Number352513-83-8
MW744.9
FormulaC34H52N18O2
SMILESC(=NNC(=N)N)(C)C1=CC(C(=NNC(=N)N)C)=CC(NC(CCCCCCCCC(NC2=CC(C(=NNC(=N)N)C)=CC(C(=NNC(=N)N)C)=C2)=O)=O)=C1
TargetTNF,Others,Interleukin,p38 MAPK

Storage & Handling

Storage-20°C
DisclaimerFor research use only

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Key Properties

No computed properties available.

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Semapimod (orb1944285)

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