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Val-Cit-PAB-MMAE

SKU: orb1307265

Description

Val-Cit-PAB-MMAE is a drug-linker conjugate for antibody-drug conjugates (ADCs), comprising the protease-cleavable Val-Cit-PAB linker and the cytotoxic payload monomethyl auristatin E (MMAE). MMAE potently inhibits tubulin polymerization, disrupting mitosis. This conjugate is widely used in ADC research for targeted cancer therapy, enabling the evaluation of drug delivery and efficacy in both in vitro and in vivo models.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number644981-35-1
MW1123.43
Purity99.06% (May vary between batches)
FormulaC58H94N10O12
SMILESCC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](N)C(C)C)cc1)C(C)C
TargetPROTAC Linker,Drug-Linker Conjugates for ADC
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (4.45 mM);DMSO:49 mg/mL (43.62 mM)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Auristatin, DrugLinkerConjugatesforADC, Drug-Linker Conjugates for ADC, DrugLinker Conjugates for ADC, inhibit, Inhibitor, Val Cit PAB MMAE, ValCitPABMMAE, Val-Cit-PAB-MMAE

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Key Properties

No computed properties available.

Protocol Information

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5 mg
$ 90.00
10 mg
$ 110.00