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Xanomeline

SKU: orb1693565

Description

Xanomeline (LY-246708) is an orally bioavailable, brain-penetrant M1/M4 muscarinic receptor agonist used in research for neurological disorders like schizophrenia. It has been investigated in both in vitro binding assays and in vivo preclinical models, demonstrating potential pro-cognitive and antipsychotic-like effects.

Research Area

Neuroscience

Images & Validation

Key Properties

CAS Number131986-45-3
MW281.42
Purity99.61%
FormulaC14H23N3OS
SMILESCCCCCCOc1nsnc1C1=CCCN(C)C1
TargetAChR

Bioactivity

In Vivo
Animal studies have shown the role of M4 and M1 receptors in modulating psychotic and behavioral disturbances and correction of negative and/or cognitive symptoms, respectively. The time to reach maximum plasma concentration (Tmax) for xanomeline is 2.5 hours, and maximum plasma concentration following xanomeline 150mg is 13.8ng/mL. Xanomeline is widely distributed, including to the CNS in animal studies, and the majority of the drug is excreted via the kidneys within 24 hours of administration.
In Vitro
In binding studies pre-incubating cells for one hour with 1 μM xanomeline, but not carbachol, reduced N-[3H]methylscopolamine saturation binding affinity but not maximal receptor density in cells .

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

mAChR M1, mAChR M4, LY 246708, LY246708, LY-246708, Xanomeline

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Quality Guarantee

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Key Properties

No computed properties available.

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Xanomeline (orb1693565)

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Available Sizes

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2 mg
¥ 1,040.00
5 mg
¥ 1,170.00
1 ml x 10 mM (in DMSO)
¥ 1,300.00
10 mg
¥ 1,690.00
25 mg
¥ 2,730.00
50 mg
¥ 4,160.00
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