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Zymosan A

SKU: orb2893573

Description

Zymosan A, a polysaccharide derived from Saccharomyces cerevisiae, is a TLR2 agonist that can upregulate ASCL2 through the TLR2 and Wnt signaling pathways, promoting the regeneration of intestinal stem cells (ISCs) after radiation-induced injury. It exhibits significant radioprotective effects, helping to prevent and alleviate IR-induced intestinal damage. Additionally, Zymosan A can induce immune responses, inflammation, anorexia, and elevated body temperature, and is commonly used to establish peritonitis models.

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number58856-93-2
TargetTLR
SolubilityH2O:< 1 mg/mL (insoluble);DMSO:1 mg/mL

Bioactivity

In Vivo
Methods: Zymosan A (25.0 mg/Kg, intraperitoneal injection, 24 and 2 hours before IR) was given to mice to observe its effect on IR-induced intestinal damage in mice. Results: The radioprotective effect of Zymosan A was even better when it was given 24 and 2 hours before IR. Zymosan A had a significant radioprotective effect on irradiated mice, and Zymosan A alleviated IR-induced intestinal damage in mice.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Zymosan A, Zymosan A from Saccharomyces cerevisia, Zymosan A from Saccharomyces cerevisiae

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Zymosan A (orb2893573)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
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50 mg
¥ 1,040.00
100 mg
¥ 1,170.00
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