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TLR8 agonist 7

SKU: orb2564585

Description

TLR8 agonist7 is a potent and plasma-stable small molecule activator of Toll-like receptor 8 (EC50 < 250 nM). It robustly induces TNFα secretion (EC50 < 1 µM) and has demonstrated significant antitumor efficacy in vivo, achieving 98% tumor growth inhibition in an MC38-HER2 mouse model. This makes it a valuable tool for immuno-oncology and innate immunity research.

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number3034750-26-7
MW1094.13
FormulaC54H63N9O16
SMILESC(NC=1C=C2C(=NC1)CCN(C(OCC3=CC(NC(CNC(CCCCCN4C(=O)C=CC4=O)=O)=O)=C(O[C@@H]5O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]5O)C=C3)=O)C2)(=O)C6(CC6)C=7C=C8C(=CC7)C=C(C(N(CCC)CCO)=O)CC(N)=N8
TargetTLR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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Protocol Information

TLR8 agonist 7 (orb2564585)

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